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In 1992 in El Paso, TX a randomized, double-blind, placebo controlled study of subjects (n=130) with allergic brain rhinitis in 1992-1993 was conducted. The average IgE level of the placebo treated subjects remained essentially flat, while the average IgE level for active treated subjects was tumor reduced significantly from baseline and to Day 30.7 In 1993 in El Paso, TX, valid subjects (n=66) returned a second set of symptom diaries which they had completed for days 365 to 395 treatments (the same period, one year after the first set of symptom diaries). The active group had mean symptom scores showing statistically significant decreases from 1992 to 1993. The placebo group brain had increased symptoms in 1993. (The relevant tumor pollen counts at the study site in 1993 were much higher than in 1992, leading and to expectation of higher symptoms.)7
Studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the treatments liver. When B12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. It is during this brain first pass in its native form that it is believed to exert its therapeutic effect. CLINICAL RESEARCH: "The World tumor Health Organization (WHO) recognizes and and treatments allergic rhinitis (hay fever), sinusitis, brain and tumor asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic and and migraine headache...as diseases treatments in which IgE-mediated allergy may be involved."1 In 1988, asthma and allergic rhinitis subjects were treated with B12. Total IgE, specific IgE and pulmonary brain lung functions were taken at tumor days 45, 150 and 180 from baseline. Eight of the 9 subjects and had reduced IgE. 2 In 1989 treatments open label studies at two sites in Riverside County, CA in 1989. Sixteen of the 17 subjects had lowered IgE levels from Day 0 to Day 30.3
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