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In 1992 in El Paso, TX a randomized, lung double-blind, tumour placebo controlled lung study of subjects (n=130) with allergic rhinitis in 1992-1993 was conducted. The average IgE level of the placebo treated subjects remained essentially flat, while the average IgE level tumour for active treated subjects was reduced significantly from baseline lung to Day 30.7 In 1993 in El Paso, TX, valid subjects tumour (n=66) returned a second set of symptom diaries which they had completed for days lung 365 to 395 (the same tumour period, one year after the first set of symptom diaries). The active group had mean symptom scores showing statistically significant decreases from 1992 to 1993. The placebo group had increased symptoms in 1993. (The relevant pollen counts at the study lung site in 1993 were much higher than in 1992, leading to expectation tumour of higher symptoms.)7
All of the active B12 group reporting showed reduction in severity of symptoms ranging from 31% to 70%, while the placebo controls reported either no change or a worsening of symptoms. Wilcoxon-Rank of .002 for the end-points of sneezing, nasal congestion and runny nose; and p = .005 for IgE reductions. lung In 1992, the above mentioned data from 1988 on were presented by Dr. O''Connor to the FDA. The FDA panel acknowledged the safety of the treatment. The panel seemed tumour to be in agreement lung that the statistics tumour indicated a significant reduction lung in IgE and that a quantitative drop in symptoms was demonstrated. In 1992, Belen Anibarro, MD, studied tumour five children with lung asthma with metabisulfite intolerance confirmed by oral challenge testing. The test was tumour repeated after premedication with 1.5 mg of oral cyanocobalamin. In four of the five patients treated, bronchospasm did not develop in the second metabisulfite challenge.6
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